54166-96-0

Basic information

• Product Name: 2-Amino-6-methoxy-benzoic acid methyl ester
• Synonyms: 2-Amino-6-methoxy-benzoic acid methyl ester;Methyl 2-Amino-6-Methoxybenzoate
• CAS NO: 54166-96-0
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.18854
• Mol File: 54166-96-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 67-68 °C
• Boiling Point: 304.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• PKA: 1.77±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-6-methoxy-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-methoxy-benzoic acid methyl ester(54166-96-0)
• EPA Substance Registry System: 2-Amino-6-methoxy-benzoic acid methyl ester(54166-96-0)

Safety Data

• Hazardous Substances Data: 54166-96-0(Hazardous Substances Data)

Usage

General Description

2-Amino-6-methoxy-benzoic acid methyl ester, also known as Methyl 2-amino-6-methoxybenzoate, is a chemical compound that belongs to the class of organic compounds known as aminobenzoic acids and derivatives. It is derived from benzoic acid, and its structure consists of a benzoic acid core with an amino group and a methoxy group attached to it. 2-Amino-6-methoxy-benzoic acid methyl ester is commonly used in the field of pharmaceuticals and organic synthesis. It has been found to have potential biological and pharmacological activities, making it a valuable compound in drug discovery and development.

Upstream product

• 606-20-2 2,6-dinitrotoluene 
• 603-12-3 2,6-dinitrobenzoic acid 
• 42087-82-1 methyl 2,6-dinitrobenzoate 
• 67-56-1 methanol 
• 53600-33-2 6-methoxyanthranilic acid 
• 4837-88-1 6-methoxy-2-nitrotoluene 
• 5460-31-1 3-nitro-o-cresol 
• 53967-73-0 2-nitro-6-methoxybenzoic acid 
• 67765-42-8 5-methoxy-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione 
• 1146214-77-8 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester 
• 606-45-1 2-methoxybenzoic acid methyl ester 
• 186581-53-3 diazomethane 
• 77901-52-1 methyl 2-methoxy-6-nitrobenzoate 

Downstream Products

• 54166-69-7 2'-carboxy-3'-methoxyoxanilic acid 1-ethyl 2'-methyl ester 
• 936479-46-8 methyl 6-chloro-2-methoxybenzoate 
• 697801-52-8 5-methoxy-4,4-dimethyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one 
• 697801-53-9 5-hydroxy-4,4-dimethyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one 
• 1380698-91-8 2-[2-amino-6-(methyloxy)phenyl]-2-propanol 
• 18362-30-6 2-chloro-6-hydroxybenzaldehyde 
• 29866-54-4 2-chloro-6-methoxybenzaldehyde 
• 1154740-80-3 6-chloro-2H-chromene-3(4H)-one 
• 1038726-89-4 2-chloro-6-methoxyphenylmethanol 

Relevant articles and documents

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

With a resurgence in interest in covalent drugs, there is a need to identify new moieties capable of cysteine bond formation that are differentiated from commonly employed systems such as acrylamide. Herein, we report on the discovery of new alkynyl benzoxazine and dihydroquinazoline moieties capable of covalent reaction with cysteine. Their utility as alternative electrophilic warheads for chemical biological probes and drug molecules is demonstrated through site-selective protein modification and incorporation into kinase drug scaffolds. A potent covalent inhibitor of JAK3 kinase was identified with superior selectivity across the kinome and improvements in in vitro pharmacokinetic profile relative to the related acrylamide-based inhibitor. In addition, the use of a novel heterocycle as a cysteine reactive warhead is employed to target Cys788 in c-KIT, where acrylamide has previously failed to form covalent interactions. These new reactive and selective heterocyclic warheads supplement the current repertoire for cysteine covalent modification while avoiding some of the limitations generally associated with established moieties.

Derivative of azaphenalene-3-ketone and preparation method and application thereof

The invention relates to a derivative of azaphenalene-3-ketone and a preparation method and an application thereof and belongs to the technical field of medicine synthesis. The structure of the derivative is as follows: a formula as shown in the descripti

QUINAZOLINE-BASED KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.