4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine

Base Information

• Chemical Name: 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine
• CAS No.: 1469863-71-5
• Molecular Formula: C₂₄H₂₈N₄O₂
• Molecular Weight: 404.512

Synonyms:4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine

Chemical Property of 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine

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Technology Process of 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine

There total 4 articles about 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

8-methoxy-4-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine (1469863-67-9) + (2-chloropropyl)dimethylamine hydrochloride (4584-49-0) → 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine (1469863-71-5)

Guidance literature:

With potassium carbonate; In chloroform; acetone; at 80 ℃;

DOI:10.1016/j.bmcl.2013.08.101

Reference yield:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine (1469863-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / 1,4-dioxane / 0.17 h / 20 °C

1.2: 72 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 36.5 h / 0 - 120 °C

3.1: potassium carbonate / acetone; chloroform / 80 °C

With boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2013.08.101

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine (1469863-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / 1,4-dioxane / 0.17 h / 20 °C

1.2: 72 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 36.5 h / 0 - 120 °C

3.1: potassium carbonate / acetone; chloroform / 80 °C

With boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2013.08.101

upstream raw materials:

8-methoxy-4-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

(2-chloropropyl)dimethylamine hydrochloride

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

4-hydroxy-benzaldehyde

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