ethyl N-Fmoc-N-γ-trityl-thioglutaminate

Base Information

• Chemical Name: ethyl N-Fmoc-N-γ-trityl-thioglutaminate
• CAS No.: 783371-47-1
• Molecular Formula: C₄₁H₃₈N₂O₄S
• Molecular Weight: 654.83
• Mol file: 783371-47-1.mol

Synonyms:ethyl N-Fmoc-N-γ-trityl-thioglutaminate

Chemical Property of ethyl N-Fmoc-N-γ-trityl-thioglutaminate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of ethyl N-Fmoc-N-γ-trityl-thioglutaminate

There total 1 articles about ethyl N-Fmoc-N-γ-trityl-thioglutaminate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Fmoc-L-Gln(Trt)-OH (132327-80-1,200623-62-7) + ethanethiol (75-08-1) → ethyl N-Fmoc-N-γ-trityl-thioglutaminate (783371-47-1)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 23 ℃; for 0.5h;

DOI:10.1016/j.tet.2004.05.107

Reference yield: 94.0%

ethyl N-Fmoc-N-γ-trityl-thioglutaminate (783371-47-1) → N-α-Fmoc-N-γ-trityl-glutaminal (334918-39-7)

Guidance literature:

With triethylsilane; palladium on activated charcoal; In dichloromethane; at 23 ℃; for 0.666667h;

DOI:10.1016/j.tet.2004.05.107

Reference yield: 36.0%

ethyl N-Fmoc-N-γ-trityl-thioglutaminate (783371-47-1) → H-Gln(Trt)-SEt (1418022-24-8)

Guidance literature:

ethyl N-Fmoc-N-γ-trityl-thioglutaminate; With piperidine; In acetonitrile; at 20 ℃; for 0.0333333h;

With acetic acid; In water; acetonitrile;

DOI:10.1002/ejoc.201300927

upstream raw materials:

Fmoc-L-Gln(Trt)-OH

ethanethiol

Downstream raw materials:

N-α-Fmoc-N-γ-trityl-glutaminal

H-Gln(Trt)-SEt