(S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester
• CAS No.: 908365-80-0
• Molecular Formula: C₂₂H₂₇NO₇
• Molecular Weight: 417.459

Synonyms:(S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property of (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester

There total 2 articles about (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate (908365-68-4) → (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester (908365-80-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 48h; Heating;

DOI:10.1039/b303789d

Reference yield:

(S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate + di-tert-butyl dicarbonate (24424-99-5) → (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester + (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester (908365-80-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 48h; Title compound not separated from byproducts.; Heating;

DOI:10.1039/b604183c

Reference yield: 24.0%

(S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester (908365-80-0) → (S)-5-[1-Ethoxycarbonyl-2-hydroxy-2-phenyl-eth-(E)-ylidene]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride;

DOI:10.1039/b303789d

upstream raw materials:

di-tert-butyl dicarbonate

(S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate

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