(S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate
• CAS No.: 908365-68-4
• Molecular Formula: C₁₇H₁₉NO₅
• Molecular Weight: 317.342

Synonyms:(S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate

Chemical Property of (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate

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Technology Process of (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate

There total 1 articles about (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-bromo-3-oxo-3-phenylpropionate (55919-47-6) + (S)-methyl 5-thioxopyrrolidine-2-carboxylate (85178-37-6) → (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate + (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate (908365-68-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; for 36h; Title compound not separated from byproducts.; Heating;

DOI:10.1039/b604183c

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate (908365-68-4) → (S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester (908365-80-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 48h; Heating;

DOI:10.1039/b303789d

Reference yield: 50.0%

(S)-methyl 5-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-ylidene)pyrrolidine-2-carboxylate (908365-68-4) → (S)-ethyl 2-(5-(hydroxymethyl)pyrrolidin-2-ylidene)-3-oxo-3-phenylpropanoate

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1039/b303789d

upstream raw materials:

ethyl 2-bromo-3-oxo-3-phenylpropionate

(S)-methyl 5-thioxopyrrolidine-2-carboxylate

Downstream raw materials:

(S)-N-tert-butoxycarbonyl-5-(1-ethoxycarbonyl-2-oxo-2-phenylethylidene)-pyrrolidine-2-carboxylic acid methyl ester

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