L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
• CAS No.: 197431-84-8
• Molecular Formula: C₃₄H₄₂N₄O₆
• Molecular Weight: 602.731
• Mol file: 197431-84-8.mol

Synonyms:L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Chemical Property of L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 2 articles about L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + 1,2-diamino-benzene (95-54-5) → L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester (197431-84-8)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/ol0063151

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + o-phenylenediamine dihydrochloride (615-28-1) → L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester (197431-84-8)

Guidance literature:

N-tert-butoxycarbonyl-L-phenylalanine; With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; In N,N-dimethyl-formamide;

o-phenylenediamine dihydrochloride; With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.03.067

Reference yield: 100.0%

L-{1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester (197431-84-8) → L-2-amino-N-[2-(2-amino-3-phenyl-propionylamino)-phenyl]-3-phenyl-propionamide-bis-hydrochloride

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/ja972135j

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

1,2-diamino-benzene

o-phenylenediamine dihydrochloride

Downstream raw materials:

(S)-2-Amino-N-[2-((S)-2-amino-3-phenyl-propionylamino)-phenyl]-3-phenyl-propionamide

L-2-(benzhydrylidene-amino)-N-{2-[2-(benzhydrylidene-amino)-3-phenyl-propionylamino]-phenyl}-3-phenyl-propionamide

C₃₈H₄₈N₆O₈

C₄₄H₅₈N₈O₁₀