(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Base Information

Chemical Name:(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane
CAS No.:1352746-40-7
Molecular Formula:C₃₅H₆₂O₈Si₂
Molecular Weight:667.043
Hs Code.:

(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Synonyms:(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

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Chemical Property of (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

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Technology Process of (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

There total 6 articles about (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352746-37-2
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-6-hydroxy-2-(2-trimethylsilylethoxy)methoxyhexyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

: 1352746-40-7
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Guidance literature:: (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-6-hydroxy-2-(2-trimethylsilylethoxy)methoxyhexyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.333333h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.064

Reference yield:

: (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-hydroxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

: 1352746-40-7
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: borane / tetrahydrofuran / -18 - 20 °C / Inert atmosphere

2.2: 3 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With oxalyl dichloride; borane; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.09.064

Reference yield:

: 1352746-32-7
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-7-tert-butyldimethysilyloxymethyl-1,4,8-trioxaspiro[4.5]-decane

: 1352746-40-7
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-5-formyl-2-(trimethylsilylethoxy)methoxypentyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: borane / tetrahydrofuran / -18 - 20 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With oxalyl dichloride; borane; lithium triethylborohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.09.064