(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Base Information

Chemical Name:(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane
CAS No.:1352746-34-9
Molecular Formula:C₃₅H₆₂O₇Si₂
Molecular Weight:651.044
Hs Code.:

(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Synonyms:(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

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Chemical Property of (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

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Technology Process of (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

There total 4 articles about (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-hydroxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1352746-34-9
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2011.09.064

Reference yield:

: 1352746-32-7
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-7-tert-butyldimethysilyloxymethyl-1,4,8-trioxaspiro[4.5]-decane

: 1352746-34-9
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.09.064

Reference yield:

: 1352746-30-5
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-oxohex-5-enyl]-7-hydroxymethyl-1,4,8-trioxaspiro[4.5]decane

: 1352746-34-9
(7R,9R)-9-[(4S)-4-benzyloxy-3,3-dimethyl-2-(2-trimethylsilylethoxy)methoxyhex-5-enyl]-7-tert-butyldimethylsilyloxymethyl-1,4,8-trioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With 1H-imidazole; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.09.064