N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Base Information

Chemical Name:N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
CAS No.:1210417-75-6
Molecular Formula:C₂₃H₂₂F₃N₅O₂
Molecular Weight:457.455
Hs Code.:

Synonyms:N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Suppliers and Price of N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

There total 16 articles about N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1210417-75-6
N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / water; tetrahydrofuran; hexane / 1 h / 60 °C

2: potassium permanganate / water / Reflux

3: ethylene dichloride hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

4: methanol; hydrogenchloride; tetrahydrofuran / 0.75 h / 20 - 60 °C

With tetrahydrofuran; hydrogenchloride; methanol; potassium fluoride; potassium permanganate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethylene dichloride hydrochloride; tri-tert-butyl phosphine; benzotriazol-1-ol; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml400307j

Reference yield:

: 162101-25-9
2,6-difluorophenylboronic acid

: 1210417-75-6
N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / water; tetrahydrofuran; hexane / 1 h / 60 °C

2: potassium permanganate / water / Reflux

3: ethylene dichloride hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

4: methanol; hydrogenchloride; tetrahydrofuran / 0.75 h / 20 - 60 °C

With tetrahydrofuran; hydrogenchloride; methanol; potassium fluoride; potassium permanganate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethylene dichloride hydrochloride; tri-tert-butyl phosphine; benzotriazol-1-ol; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml400307j