methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

Base Information

Chemical Name:methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride
CAS No.:1316756-78-1
Molecular Formula:C₁₅H₁₈F₃NO₃*ClH
Molecular Weight:353.769
Hs Code.:

Synonyms:methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

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Chemical Property of methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

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Technology Process of methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

There total 8 articles about methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1316756-77-0
methyl 2-{(2R,4S,5S)-5-(tert-butoxycarbonylamino)-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate

: 1316756-78-1
methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 1316756-78-1
methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / tetrahydrofuran / 2 h / -78 - 0 °C

1.2: -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 20 °C

2.2: 0.5 h

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h

3.2: 1 h / -78 °C

4.1: dichloromethane / 3 h / -78 - 20 °C

5.1: toluene-4-sulfonic acid / methanol / 14 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; oxalyl dichloride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1316756-74-7
tert-butyl (4S)-4-{(1S)-3-hydroxy-1-[4-(trifluoromethyl)phenyl]propyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 1316756-78-1
methyl 2-{(2R,4S,5S)-5-amino-4-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h

1.2: 1 h / -78 °C

2.1: dichloromethane / 3 h / -78 - 20 °C

3.1: toluene-4-sulfonic acid / methanol / 14 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; oxalyl dichloride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;