(R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

Base Information

Chemical Name:(R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid
CAS No.:1351168-85-8
Molecular Formula:C₁₄H₁₆O₆
Molecular Weight:280.277
Hs Code.:

Synonyms:(R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

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Chemical Property of (R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

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Technology Process of (R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

There total 2 articles about (R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104211-04-3
L-O-monobenzyl tartaric acid

: 77-76-9
2,2-dimethoxy-propane

: 1351168-85-8
(R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

Guidance literature:: With toluene-4-sulfonic acid; at 20 ℃; for 4h;

Reference yield:

: 119770-87-5,104211-01-0
(2R,3R)-diethyl 2-(benzyloxy)-3-hydroxysuccinate

: 1351168-85-8
(R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

2: toluene-4-sulfonic acid / 4 h / 20 °C

With lithium hydroxide monohydrate; water; toluene-4-sulfonic acid; In tetrahydrofuran;

Reference yield:

: 1351168-85-8
(R)-2-(benzyloxy)-2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

: 1351168-21-2
tert-butyl 4-((3S,4S)-4-(benzyloxy)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Cooling with ice

2.1: triethylsilane / palladium 10% on activated carbon / dichloromethane / Inert atmosphere

3.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 20 °C

3.2: 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h

5.1: potassium carbonate / dimethyl sulfoxide / 70 °C / Inert atmosphere

6.1: trans-1,2-cyclohexanediamine; copper(I) triflate benzene complex / dimethyl sulfoxide / 110 °C / Inert atmosphere

With triethylsilane; dmap; potassium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; copper(I) triflate benzene complex; palladium 10% on activated carbon; trans-1,2-cyclohexanediamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;