C₅₅H₆₇N₅O₁₀Si₂

Base Information

• Chemical Name: C₅₅H₆₇N₅O₁₀Si₂
• CAS No.: 171762-81-5
• Molecular Formula: C₅₅H₆₇N₅O₁₀Si₂
• Molecular Weight: 1014.34
• Mol file: 171762-81-5.mol

Synonyms:C₅₅H₆₇N₅O₁₀Si₂

Chemical Property of C₅₅H₆₇N₅O₁₀Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₆₇N₅O₁₀Si₂

There total 19 articles about C₅₅H₆₇N₅O₁₀Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-Methyl-5-methyluridine (55486-09-4) → C55H67N5O10Si2 (171762-81-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / I₂, PPh₃, pyridine / 5 h / Ambient temperature

2: 89 percent / NaN₃ / dimethylformamide / 24 h / 60 °C

3: 87 percent / DMAP, imidazole / dimethylformamide / 24 h / Ambient temperature

4: 72 percent / SnCl₂*2H₂O / methanol / 20 h / Ambient temperature

5: 1.) Et₃N, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, HOBT, 2.) Et₃N / 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h

With pyridine; 1H-imidazole; dmap; sodium azide; iodine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; tin(ll) chloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

O-2,2'-cyclo-5-methyluridine (22423-26-3) → C55H67N5O10Si2 (171762-81-5)

Guidance literature:

Multi-step reaction with 13 steps

1: 72 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

2: 82 percent / Et₃N, DMAP, pyridine / CH₂Cl₂ / 40 h / Ambient temperature

3: 79 percent / AIBN / benzene / 20 h / Heating

4: 90 percent / aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature

5: 92 percent / DBU / acetonitrile / 18 h / Ambient temperature

6: 83 percent / PPh₃, diisopropylazodicarboxylate / toluene / 50 h / Ambient temperature

7: 92 percent / NaOMe / methanol / 1 h / Ambient temperature

8: 94 percent / NaH / tetrahydrofuran / 17 h / Ambient temperature

9: 61 percent / OsO₄, N-methylmorpholine-N-oxide, H₂O / acetone / 18 h / Ambient temperature

10: 83 percent / H₂ / 10percent Pd/C / methanol / 18 h / 760 Torr / Ambient temperature

11: 81 percent / aq. NaIO₄ / dioxane / 18 h / Ambient temperature

12: 92 percent / aq. NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 30 h / Ambient temperature

13: 1.) Et₃N, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, HOBT, 2.) Et₃N / 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h

With pyridine; 1H-imidazole; dmap; sodium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; water; hydrogen; sodium methylate; sodium hydride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → C55H67N5O10Si2 (171762-81-5)

Guidance literature:

Multi-step reaction with 13 steps

1: 72 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

2: 82 percent / Et₃N, DMAP, pyridine / CH₂Cl₂ / 40 h / Ambient temperature

3: 79 percent / AIBN / benzene / 20 h / Heating

4: 90 percent / aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature

5: 92 percent / DBU / acetonitrile / 18 h / Ambient temperature

6: 83 percent / PPh₃, diisopropylazodicarboxylate / toluene / 50 h / Ambient temperature

7: 92 percent / NaOMe / methanol / 1 h / Ambient temperature

8: 94 percent / NaH / tetrahydrofuran / 17 h / Ambient temperature

9: 61 percent / OsO₄, N-methylmorpholine-N-oxide, H₂O / acetone / 18 h / Ambient temperature

10: 83 percent / H₂ / 10percent Pd/C / methanol / 18 h / 760 Torr / Ambient temperature

11: 81 percent / aq. NaIO₄ / dioxane / 18 h / Ambient temperature

12: 92 percent / aq. NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 30 h / Ambient temperature

13: 1.) Et₃N, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, HOBT, 2.) Et₃N / 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h

With pyridine; 1H-imidazole; dmap; sodium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; water; hydrogen; sodium methylate; sodium hydride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;

upstream raw materials:

5'-Amino-3'-tert-butyldiphenylsilyl-5'-deoxythymidine

[(2S,3R,4R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

1-[(2R,3R,4R,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

O-2,2'-cyclo-5-methyluridine

Downstream raw materials:

C₄₄H₄₉N₅O₁₂