1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

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Chemical Name:1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride
CAS No.:92901-00-3
Molecular Formula:C₃₆H₄₀N₄O₅*ClH
Molecular Weight:645.198
Hs Code.:

Synonyms:1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

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Chemical Property of 1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

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Technology Process of 1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

There total 6 articles about 1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 41852-55-5
α-(aminomethyl)-3,5-bis(benzyloxy)benzyl alcohol

: 23673-07-6
4-chloro-2-(diethylamino)-6,7-dimethoxyquinazoline

: 92901-00-3
1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

Guidance literature:: In ethanol; at 110 ℃; for 60h;
DOI:10.1021/jm00379a004

Reference yield:

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 92901-00-3
1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1N NaOH / 1.) THF, RT, 8 h, 2.) EtOH, 130 deg C, 6 h

2: 85 percent / POCl₃, N,N-dimethylaniline / 1.5 h / Heating

3: 85 percent / ethanol / 60 h / 110 °C

With sodium hydroxide; N,N-dimethyl-aniline; trichlorophosphate; In ethanol;
DOI:10.1021/jm00379a004

Reference yield:

: 14615-72-6
3,5-dibenzyloxybenzaldehyde

: 92901-00-3
1-(3,5-Bis-benzyloxy-phenyl)-2-(2-diethylamino-6,7-dimethoxy-quinazolin-4-ylamino)-ethanol; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: ZnI₂ / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 85 percent / ethanol / 60 h / 110 °C

With lithium aluminium tetrahydride; zinc(II) iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00379a004