1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate
CAS No.:174690-41-6
Molecular Formula:C₃₁H₄₅N₂O₇P
Molecular Weight:588.681
Hs Code.:

1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Synonyms:1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

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Technology Process of 1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

There total 5 articles about 1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 174690-42-7
(2R,5R)-5-[4'-Benzyloxy-5-(diethoxy-phosphorylmethyl)-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

: 174690-41-6
1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1002/hlca.19950780810

Reference yield:

: 51760-23-7
1-bromo-3,5-bis(bromomethyl)benzene

: 174690-41-6
1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / xylene / 2 h / Heating

2: 95 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / 1.67 h / -70 °C

3: 2M aq. Na₂CO₃, PPh₃, Pd(OAc)2 / ethanol; toluene / 100 °C / ultrasonic bath

4: 72 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

With palladium diacetate; n-butyllithium; hydrogen; sodium carbonate; diisopropylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; toluene; xylene;
DOI:10.1002/hlca.19950780810

Reference yield:

: 51760-22-6
5-bromo-1,3-dihydroxymethylbenzene

: 174690-41-6
1,1-dimethylethyl (2R,5R)-5-<<5-<(diethoxyphopsphoryl)methyl>-4'-hydroxy(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: PPh₃ / toluene / 2 h / 80 °C

2: 47 percent / xylene / 2 h / Heating

3: 95 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / 1.67 h / -70 °C

4: 2M aq. Na₂CO₃, PPh₃, Pd(OAc)2 / ethanol; toluene / 100 °C / ultrasonic bath

5: 72 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

With palladium diacetate; n-butyllithium; hydrogen; sodium carbonate; diisopropylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; toluene; xylene;
DOI:10.1002/hlca.19950780810