glycine benzyl ester; hydrobromide

Base Information

• Chemical Name: glycine benzyl ester; hydrobromide
• CAS No.: 104403-70-5
• Molecular Formula: BrH*C₉H₁₁NO₂
• Molecular Weight: 246.104
• Mol file: 104403-70-5.mol

Synonyms:glycine benzyl ester; hydrobromide

Chemical Property of glycine benzyl ester; hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of glycine benzyl ester; hydrobromide

There total 3 articles about glycine benzyl ester; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-[(Benzyloxycarbonylmethyl-amino)-methylene]-malonic acid diethyl ester (126046-00-2) → glycine benzyl ester; hydrobromide (104403-70-5)

Guidance literature:

With bromine; In chloroform; Ambient temperature;

DOI:10.1055/s-1989-27312

Reference yield: 66.0%

C19H21Cl2N2O5P (77930-09-7) → glycine benzyl ester; hydrobromide (104403-70-5)

Guidance literature:

With hydrogen bromide; In acetic acid; for 0.333333h;

DOI:10.1016/S0040-4020(01)97957-8

Reference yield:

benzyl bromide (100-39-0) → glycine benzyl ester; hydrobromide (104403-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Et₃N / acetone / 0.5 h / Ambient temperature

2: 75 percent / 4percent Br₂ / CHCl₃ / Ambient temperature

With bromine; triethylamine; In chloroform; acetone;

DOI:10.1055/s-1989-27312

upstream raw materials:

2-[(Benzyloxycarbonylmethyl-amino)-methylene]-malonic acid diethyl ester

C₁₉H₂₁Cl₂N₂O₅P

benzyl bromide

Downstream raw materials:

Cbz-Gly-Gly-OBn

Refernces

• 1、 Mulliez, M.. "ETUDE D'UN SCHEMA DE SYNTHESE PEPTIDIQUE INTRAMOLECULAIRE A L'AIDE DE DERIVES DU PHOSPHORE TETRAEDRIQUE". . p. 2027 - 2041. Retrieved 2007/10/02.