2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

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Chemical Name:2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol
CAS No.:1092444-13-7
Molecular Formula:C₁₉H₂₅N₅O₂
Molecular Weight:355.44
Hs Code.:

Synonyms:2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

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Chemical Property of 2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

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Technology Process of 2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

There total 9 articles about 2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092444-33-1
benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

: 188538-25-2
1,3-di-tert-butyldimethylsilyloxy-2-propylamine

: 1092444-13-7
2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

: C₃₆H₆₁N₅O₄Si₂

Guidance literature:: benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester; With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 0.0833333h;

1,3-di-tert-butyldimethylsilyloxy-2-propylamine; In toluene; at 100 ℃; for 12h; Product distribution / selectivity;

Reference yield:

: 151521-49-2
4-isopropyl-1 H-pyrazol-5-amine

: 1092444-13-7
2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol / 16 h / Heating / reflux

1.2: pH 3

2.1: trichlorophosphate / 16 h / Heating / reflux

3.1: ethanol / 3 h / Heating / reflux

4.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

5.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

5.2: 12 h / 100 °C

With sodium; sodium t-butanolate; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1092443-98-5
benzyl-(5-chloro-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)-amine

: 1092444-13-7
2-(7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

2.2: 12 h / 100 °C

With sodium t-butanolate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene;