benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

Base Information

Chemical Name:benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester
CAS No.:1092444-33-1
Molecular Formula:C₂₁H₂₅ClN₄O₂
Molecular Weight:400.908
Hs Code.:

Synonyms:benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

Suppliers and Price of benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 99% ,99.9%, ^*data from raw suppliers

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Technology Process of benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

There total 8 articles about benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1092443-98-5
benzyl-(5-chloro-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)-amine

: 24424-99-5
di-tert-butyl dicarbonate

: 1092444-33-1
benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

Guidance literature:: With dmap; In tetrahydrofuran; at 25 ℃; for 20h;
DOI:10.1021/jm100732t

Reference yield:

: 625-28-5
Isovaleronitrile

: 1092444-33-1
benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 16.5 h / -78 - 20 °C

2.1: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux

3.1: ethanol; sodium / 16 h / Reflux

3.2: pH 3

4.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / Reflux

5.1: ethanol / 3 h / Reflux

6.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

With dmap; ethanol; sodium; hydrazine hydrate; acetic acid; N,N-dimethyl-aniline; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; ethanol;

Reference yield:

: 771510-15-7
2-formyl-3-methylbutanenitrile

: 1092444-33-1
benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux

2.1: ethanol; sodium / 16 h / Reflux

2.2: pH 3

3.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / Reflux

4.1: ethanol / 3 h / Reflux

5.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

With dmap; ethanol; sodium; hydrazine hydrate; acetic acid; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; ethanol;