N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Base Information

Chemical Name:N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide
CAS No.:1394431-49-2
Molecular Formula:C₂₃H₂₂N₂O₄S
Molecular Weight:422.505
Hs Code.:

Synonyms:N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Suppliers and Price of N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

There total 8 articles about N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394431-81-2
N-(4-bromobenzyl)-5-methoxy-1H-indole-2-sulfonamide

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 1394431-49-2
N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 3h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2016.08.018

Reference yield:

: 1006-94-6
5-methoxylindole

: 1394431-49-2
N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere

2.2: 2.25 h / -70 - 20 °C / Inert atmosphere

3.1: N-chloro-succinimide / dichloromethane / 2 h / 5 °C

4.1: dichloromethane / Cooling with ice

5.1: sodium hydroxide / ethanol / Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 3 h / Reflux; Inert atmosphere

With N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2016.08.018

Reference yield:

: 56995-12-1
1-benzenesulfonyl-5-methoxy-1H-indole

: 1394431-49-2
N-((4'-(hydroxymethyl)biphenyl-4-yl)methyl)-5-methoxy-1H-indole-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere

1.2: 2.25 h / -70 - 20 °C / Inert atmosphere

2.1: N-chloro-succinimide / dichloromethane / 2 h / 5 °C

3.1: dichloromethane / Cooling with ice

4.1: sodium hydroxide / ethanol / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 3 h / Reflux; Inert atmosphere

With N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene; 5.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2016.08.018