5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

Base Information

Chemical Name:5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester
CAS No.:478855-32-2
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

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Chemical Property of 5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

Chemical Property:

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Technology Process of 5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

There total 7 articles about 5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[3-(2-phenylacetylamino-ethyl)-phenoxy]-pentanoic acid methyl ester

: 478855-32-2
5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

Guidance literature:: With trichlorophosphate; In dichloromethane; for 3h; Heating;
DOI:10.1021/jm020831a

Reference yield:

: 1700-37-4
3-Benzyloxybenzaldehyde

: 478855-32-2
5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NH₄OAc; AcOH / Heating

2: LiAlH₄ / diethyl ether; tetrahydrofuran / Heating

3: 5percent aq. NaOH / CH₂Cl₂ / 2 h / 20 °C

4: conc. HCl / ethanol / 4 h / Heating

5: K₂CO₃ / acetone / Heating

6: POCl₃ / CH₂Cl₂ / 3 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; 3: Schotten-Baumann reaction / 6: Bischler-Napieralski cyclodehydration;
DOI:10.1021/jm020831a

Reference yield:

: 51061-22-4
2-(3-benzyloxyphenyl)ethylamine

: 478855-32-2
5-(1-benzyl-3,4-dihydro-isoquinolin-6-yloxy)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 5percent aq. NaOH / CH₂Cl₂ / 2 h / 20 °C

2: conc. HCl / ethanol / 4 h / Heating

3: K₂CO₃ / acetone / Heating

4: POCl₃ / CH₂Cl₂ / 3 h / Heating

With hydrogenchloride; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane; acetone; 1: Schotten-Baumann reaction / 4: Bischler-Napieralski cyclodehydration;
DOI:10.1021/jm020831a