4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

Base Information

Chemical Name:4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine
CAS No.:1428929-27-4
Molecular Formula:C₂₀H₂₁F₃N₂O
Molecular Weight:362.395
Hs Code.:

Synonyms:4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

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Chemical Property of 4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

Chemical Property:

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Technology Process of 4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

There total 10 articles about 4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1428929-33-2
4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanone

: 1428929-27-4
4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

Guidance literature:: 4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanone; With titanium(IV) isopropylate; ammonia; In ethanol; at 20 ℃; for 6h; Inert atmosphere;

With sodium tetrahydroborate; ethanol; for 18h;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1428929-27-4
4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

2.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

3.1: 18 h / 130 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

4.2: 18 h / 0 - 20 °C

5.1: hydrogenchloride; water / acetone

6.1: ammonia; titanium(IV) isopropylate / ethanol / 6 h / 20 °C / Inert atmosphere

6.2: 18 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; thionyl chloride; ammonia; water; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil; 4.1: |Wittig-Horner Reaction;

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 1428929-27-4
4-[[3-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexanamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2.1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

3.1: sodium hydroxide / ethanol; water / 1 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

5.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

6.1: 18 h / 130 °C

7.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

7.2: 18 h / 0 - 20 °C

8.1: hydrogenchloride; water / acetone

9.1: ammonia; titanium(IV) isopropylate / ethanol / 6 h / 20 °C / Inert atmosphere

9.2: 18 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; ammonia; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil; 7.1: |Wittig-Horner Reaction;