methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Base Information

Chemical Name:methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride
CAS No.:1207436-26-7
Molecular Formula:C₁₄H₁₇Cl₂NO₂*ClH
Molecular Weight:338.661
Hs Code.:

Synonyms:methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

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Chemical Property of methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

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Technology Process of methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

There total 7 articles about methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1207438-65-0
tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-methoxy-2-oxoethyl]piperidine-1-carboxylate

: 1207436-26-7
methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Guidance literature:: With hydrogenchloride; ethanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-43-4
tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

: 1207436-26-7
methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; water / 5 h / Reflux

2.1: sodium hydroxide / water

2.2: 20 h / 20 °C

2.3: pH Ca_. 3

3.1: methanol / 0 - 20 °C

4.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; methanol; ethanol; water; hydrogen bromide; sodium hydroxide; In water;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-51-4
(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

: 1207436-26-7
methyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water

1.2: 20 h / 20 °C

1.3: pH Ca_. 3

2.1: methanol / 0 - 20 °C

3.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; methanol; ethanol; sodium hydroxide; In water;
DOI:10.1016/j.bmc.2013.05.025