N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine

Base Information

• Chemical Name: N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine
• CAS No.: 175916-08-2
• Molecular Formula: C₃₀H₃₀BrN₅O₇
• Molecular Weight: 652.501

Synonyms:N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine

Chemical Property of N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine

There total 7 articles about N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C30H31N5O8 (175916-38-8) → N2-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine (175916-08-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In acetonitrile; for 0.75h;

DOI:10.1021/ja952322m

Reference yield:

benzoyl chloride (98-88-4) → N2-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine (175916-08-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / pyridine, DMAP

2: 1.) N-methyl-N-(trimethylsilyl)trifluoroacetamide, 2.) trimethylsilyl triflate

3: TBAF / tetrahydrofuran / 4 h / Ambient temperature

4: 75 percent / PPh₃, CBr₄ / acetonitrile / 0.75 h

With pyridine; dmap; carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja952322m

Reference yield:

Benzoic acid (2R,3S,4R)-4-hydroxy-2-(2-hydroxy-ethyl)-5-methoxy-tetrahydro-furan-3-ylmethyl ester (441044-21-9) → N2-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine (175916-08-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / imidazole / tetrahydrofuran

2: 74 percent / pyridine, DMAP

3: 1.) N-methyl-N-(trimethylsilyl)trifluoroacetamide, 2.) trimethylsilyl triflate

4: TBAF / tetrahydrofuran / 4 h / Ambient temperature

5: 75 percent / PPh₃, CBr₄ / acetonitrile / 0.75 h

With pyridine; 1H-imidazole; dmap; carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja952322m

upstream raw materials:

C₃₀H₃₁N₅O₈

benzoyl chloride

Benzoic acid (2R,3S,4R)-4-hydroxy-2-(2-hydroxy-ethyl)-5-methoxy-tetrahydro-furan-3-ylmethyl ester

C₃₈H₄₂O₇Si

Downstream raw materials:

C₇₀H₇₇N₁₁O₁₄SSi

C₅₄H₅₉N₁₁O₁₆S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 175916-08-2 N²-isobutyryl-9-{2'-benzoyl-3'-[(benzoyloxy)methyl]-6'-bromo-3',5',6'-trideoxy-β-allofuranosyl}guanine

Send

Send

Metric Ton KG G Pound L ML

Send

Send