(2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

Base Information

Chemical Name:(2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane
CAS No.:198208-20-7
Molecular Formula:C₂₃H₃₀N₄O₄
Molecular Weight:426.516
Hs Code.:

Synonyms:(2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

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Chemical Property of (2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

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Technology Process of (2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

There total 5 articles about (2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 198208-15-0
(2R,3R,4S,5S)-5-[N-(tert-butyloxycarbonyl)amino]-2,3-epoxy-4-hydroxy-1,6-diphenylhexane

: 198208-20-7
(2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

Guidance literature:: With sodium azide; diethylaluminium chloride; In toluene; 1 h, -78 deg C then 16 h, 25 deg C;
DOI:10.1016/S0040-4039(98)01733-X

Reference yield:

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 198208-20-7
(2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / -78 °C

2: 50 percent / K₂CO₃ / ethanol / 0.42 h

3: 73 percent / NaBH₄ / methanol / 1 h / 0 °C

4: 70 percent / m-CPBA / CH₂Cl₂ / Ambient temperature

5: NaN₃, NH₄Cl / methanol; H₂O / 48 h / 80 °C

With sodium tetrahydroborate; sodium azide; potassium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo971202p

Reference yield:

: 176504-90-8
dimethyl [(3S)-4-phenyl-3-[N-(tert-butyloxycarbonyl)amino]-2-oxobutyl]phosphonate

: 198208-20-7
(2S,3S,4S,5S)-2-azido-5-[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1,6-diphenylhexane

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / K₂CO₃ / ethanol / 0.42 h

2: 73 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 70 percent / m-CPBA / CH₂Cl₂ / Ambient temperature

4: NaN₃, NH₄Cl / methanol; H₂O / 48 h / 80 °C

With sodium tetrahydroborate; sodium azide; potassium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo971202p