4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Base Information

• Chemical Name: 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide
• CAS No.: 117535-97-4
• Molecular Formula: C₂₁H₂₄ClNO₃
• Molecular Weight: 373.879
• Mol file: 117535-97-4.mol

Synonyms:4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Chemical Property of 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

There total 4 articles about 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-amino-4-phenyl-2-butanone hydrochloride (5440-27-7) + [4-(3-Chloro-propoxy)-phenyl]-acetyl chloride (117535-96-3) → 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117535-97-4)

Guidance literature:

With sodium acetate; In chloroform; water; Ambient temperature; overnight;

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117535-97-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / K₂CO₃ / acetone / 40 h / Heating

2: 65 percent / 1N NaOH / 20 h / Ambient temperature

3: 75 percent / SOCl₂ / 6 h / Heating

4: 82 percent / sodium acetate / CHCl₃; H₂O / Ambient temperature; overnight

With sodium hydroxide; thionyl chloride; sodium acetate; potassium carbonate; In chloroform; water; acetone;

Reference yield:

methyl [4-(3-chloropropoxy)phenyl]acetate (69182-96-3) → 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117535-97-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / 1N NaOH / 20 h / Ambient temperature

2: 75 percent / SOCl₂ / 6 h / Heating

3: 82 percent / sodium acetate / CHCl₃; H₂O / Ambient temperature; overnight

With sodium hydroxide; thionyl chloride; sodium acetate; In chloroform; water;

upstream raw materials:

3-amino-4-phenyl-2-butanone hydrochloride

[4-(3-Chloro-propoxy)-phenyl]-acetyl chloride

Methyl 4-hydroxyphenylacetate

4-(3-chloropropoxy)phenylacetic acid

Downstream raw materials:

4-<3-(N-piperidyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

4-<3-(N-morpholinyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

3-<4-(3-ethoxypropoxy)phenyl>-4-methyl-5-benzylidenepyrrolin-2-one