2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide

Base Information

• Chemical Name: 2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide
• CAS No.: 172795-96-9
• Molecular Formula: C₂₂H₂₄N₂O₃
• Molecular Weight: 364.444
• Mol file: 172795-96-9.mol

Synonyms:2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide

Chemical Property of 2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide

There total 1 articles about 2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

7-bromo-8-(methyloxy)quinoline (36748-99-9) + 5-methoxy-2-(pivaloylamino)phenylboronic acid → 2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide (172795-96-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; for 72h; Heating;

DOI:10.1016/0040-4020(95)00726-O

Reference yield: 79.0%

2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide (172795-96-9) → 7-(2-amino-5-methoxyphenyl)-8-methoxyquinoline (172795-97-0)

Guidance literature:

With sulfuric acid; for 6h; Heating;

DOI:10.1016/0040-4020(95)00726-O

Reference yield:

2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide (172795-96-9) → 7-(2-azido-5-methoxyphenyl)-8-methoxyquinoline (172795-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / 20percent sulfuric acid / 6 h / Heating

2: 1.) conc. sulfuric acid, sodium nitrite; 2.) sodium azide / 1.) water, 45 min; 2.) water, 40 min

With sodium azide; sulfuric acid; sodium nitrite;

DOI:10.1016/0040-4020(95)00726-O

upstream raw materials:

7-bromo-8-(methyloxy)quinoline

Downstream raw materials:

7-(2-amino-5-methoxyphenyl)-8-methoxyquinoline

7-(2-azido-5-methoxyphenyl)-8-methoxyquinoline