(R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide
• CAS No.: 1323723-11-0
• Molecular Formula: C₂₄H₂₇NO₃S
• Molecular Weight: 409.549
• Mol file: 1323723-11-0.mol

Synonyms:(R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide

Chemical Property of (R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide

There total 2 articles about (R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(4-(benzyloxy)butylidene)-4-methylbenzenesulfonamide (1323722-71-9) + phenylboronic acid (98-80-6) → (R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide (1323723-11-0)

Guidance literature:

With C₄₀H₃₈O₂Rh₂; In 1,4-dioxane; at 70 ℃; for 6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ja2046217

Reference yield:

4-benzyloxybutanal (5470-84-8) + toluene-4-sulfonamide (70-55-3) → (R)-N-[(1-phenyl-4-(phenylmethoxy)butyl)]-4-methylbenzenesulfonamide (1323723-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid; sodium 4-methylbenzenesulfinate / water / 20 °C / Inert atmosphere

2: C₄₀H₃₈O₂Rh₂ / 1,4-dioxane / 6 h / 70 °C / Inert atmosphere; Molecular sieve

With formic acid; C₄₀H₃₈O₂Rh₂; sodium 4-methylbenzenesulfinate; In 1,4-dioxane; water;

DOI:10.1021/ja2046217

upstream raw materials:

N-(4-(benzyloxy)butylidene)-4-methylbenzenesulfonamide

phenylboronic acid

4-benzyloxybutanal

toluene-4-sulfonamide