6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

Base Information

Chemical Name:6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
CAS No.:729572-39-8
Molecular Formula:C₂₃H₂₁NO₃S
Molecular Weight:391.491
Hs Code.:

Synonyms:6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

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Chemical Property of 6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

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Technology Process of 6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

There total 7 articles about 6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ylpyridine-2-sulfonate

: 729572-39-8
6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; water; for 0.5h;
DOI:10.1021/acs.joc.1c01649

Reference yield: 93.0%

: 729572-37-6
1-(2-bromobenzyl)-2-p-toluenesulfonamide-1,2,3,4-tetrahydroisoquinolin-7-ol

: 729572-39-8
6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

Guidance literature:: 1-(2-bromobenzyl)-2-p-toluenesulfonamide-1,2,3,4-tetrahydroisoquinolin-7-ol; With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate; In N,N-dimethyl acetamide; at 110 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In N,N-dimethyl acetamide; water; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.12.022

Reference yield:

: 51-67-2
tyrosamine

: 729572-39-8
6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Inert atmosphere

3.1: chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / N,N-dimethyl acetamide / 1 h / 110 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate; In N,N-dimethyl acetamide; 2.1: Pictet-Spengler cyclisation;
DOI:10.1016/j.tet.2011.12.022