6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

Base Information

Chemical Name:6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone
CAS No.:729572-42-3
Molecular Formula:C₂₃H₂₁NO₂S
Molecular Weight:375.491
Hs Code.:

Synonyms:6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

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Chemical Property of 6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

Chemical Property:

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Technology Process of 6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

There total 8 articles about 6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 729572-41-2
6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-yl trifluoromethanesulfonate

: 729572-42-3
6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

Guidance literature:: With palladium diacetate; acetic acid; triethylamine; 1,2-bis-(diphenylphosphino)ethane; In N,N-dimethyl-formamide; at 80 ℃; for 6h; Inert atmosphere;
DOI:10.1021/acs.joc.1c01649

Reference yield:

: 729572-39-8
6-benzenesulfonyl-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

: 729572-42-3
6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 77 percent / DPPF; Et₃N; HCOO₂H / Pd(OAc)2 / dimethylformamide / 24 h / 80 °C

With 2,6-dimethylpyridine; 1,1'-bis-(diphenylphosphino)ferrocene; Peroxyformic acid; triethylamine; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.04.194

Reference yield:

: 259263-97-3
4-methyl-N-[2-(4-hydroxyphenyl)ethyl]benzenesulfonamide

: 729572-42-3
6-tosyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / 5 h / 70 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: palladium(II) trifluoroacetate; silver trifluoroacetate / acetic acid / 36 h / 80 °C / Sealed tube

4: zinc; ammonium chloride / tetrahydrofuran; water / 0.5 h

5: triethylamine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

6: palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; acetic acid; triethylamine / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

With palladium(II) trifluoroacetate; palladium diacetate; silver trifluoroacetate; ammonium chloride; acetic acid; triethylamine; trifluoroacetic acid; 1,2-bis-(diphenylphosphino)ethane; zinc; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.1c01649