(3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

Base Information

Chemical Name:(3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione
CAS No.:787633-76-5
Molecular Formula:C₃₁H₂₆Cl₂N₂O₂Se
Molecular Weight:608.426
Hs Code.:

Synonyms:(3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

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Chemical Property of (3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

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Technology Process of (3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

There total 6 articles about (3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 787633-75-4
(S)-α-(4-chlorophenyl)-α-[(R)-N-[1-(4-chlorophenyl)ethyl]-N-(cinnamoyl)amino] acetamide

: 34837-55-3
Phenylselenyl bromide

: 787633-76-5
(3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

Guidance literature:: With silver trifluoromethanesulfonate; N,N-dimethyl-formamide; In acetonitrile; for 6h;

Reference yield:

: 27298-99-3
(R)-1-(4-chlorophenyl)ethylamine

: 787633-76-5
(3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃; TBAI / acetonitrile

2: pyridine / CHCl₃

3: aq. NaOH / methanol; tetrahydrofuran

4: NH₄Cl; HOBt; DIPEA / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

5: silver triflate; DMF / acetonitrile

With pyridine; sodium hydroxide; silver trifluoromethanesulfonate; tetra-(n-butyl)ammonium iodide; potassium carbonate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.02.018

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 787633-76-5
(3S)-1,3,6,7-tetrahydro-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-phenyl-6-(phenylseleno)-1,4-diazepine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃; TBAI / acetonitrile

2: pyridine / CHCl₃

3: aq. NaOH / methanol; tetrahydrofuran

4: NH₄Cl; HOBt; DIPEA / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

5: silver triflate; DMF / acetonitrile

With pyridine; sodium hydroxide; silver trifluoromethanesulfonate; tetra-(n-butyl)ammonium iodide; potassium carbonate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.02.018