2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid

Base Information

• Chemical Name: 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid
• CAS No.: 169772-26-3
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol file: 169772-26-3.mol

Synonyms:2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid

Chemical Property of 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid

There total 3 articles about 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate (42022-53-7) → 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid (169772-26-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01147

Reference yield:

2,6-diisopropylbenzenamine (24544-04-5) → 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid (169772-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 1 h / 0 °C

2: KOH / methanol / 15 °C

With pyridine; potassium hydroxide; In methanol; dichloromethane;

DOI:10.1021/jo00122a020

Reference yield:

ethyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate (609798-47-2) → 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid (169772-26-3)

Guidance literature:

With water; triethylamine; In methanol; at 20 ℃; for 3h;

DOI:10.1039/c8md00185e

upstream raw materials:

methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate

2,6-diisopropylbenzenamine

ethyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate

Downstream raw materials:

2,6-diisopropylphenyl isocyanate

N-(2-(isopropylthio)phenyl)-N'-(2,6-diisopropylphenyl)-oxalamide

N-(2-(methylthio)phenyl)-N'-(2,6-diisopropylphenyl)-oxalamide

N-(2-(phenylthio)phenyl)-N'-(2,6-diisopropylphenyl)-oxalamide