2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

Base Information

Chemical Name:2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate
CAS No.:1574379-22-8
Molecular Formula:C₂₉H₃₂N₂O₇
Molecular Weight:520.582
Hs Code.:

Synonyms:2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

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Chemical Property of 2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

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Technology Process of 2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

There total 6 articles about 2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 112661-85-5
5-(benzyloxycarbonylamino)-4-oxopentanoic acid

: 210244-51-2
1-[2'-(hydroxy)ethyl]-2-ethyl-3-benzyloxy-4(1H)-pyridinone

: 1574379-22-8
2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 24h;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1574379-22-8
2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; 1,4-dioxane

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h

With dmap; dicyclohexyl-carbodiimide; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 4940-11-8
2-ethyl-3-hydroxy-4-pyranone

: 1574379-22-8
2-(3-(benzyloxy)-2-ethyl-4-oxopyridin-1(4H)-yl)ethyl 5-(((benzyloxy)carbonyl)amino)-4-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 60 °C / Reflux

2.1: sodium hydroxide / ethanol; water / 18 h / Reflux

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.7b00346