1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

Base Information

Chemical Name:1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine
CAS No.:514211-09-7
Molecular Formula:C₂₅H₂₉N₃O₃Si
Molecular Weight:447.609
Hs Code.:

Synonyms:1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

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Chemical Property of 1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

Chemical Property:

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Technology Process of 1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

There total 5 articles about 1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 514211-15-5
3'-O-tert-butyldiphenylsilyl-2'-deoxycytidine

: 514211-09-7
1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / triphenylphosphine; tetrabromomethane / dioxane / 96 h / 20 °C

2: 67 percent / DBU / dimethylformamide / 96 h / 20 °C

With carbon tetrabromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.059

Reference yield:

: 67219-55-0
4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

: 514211-09-7
1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole; pyridine / 16 h / 20 °C

2: ammonia / methanol / 16 h / 20 °C

3: 8.7 g / acetic acid / 1 h / 20 °C

4: 66 percent / triphenylphosphine; tetrabromomethane / dioxane / 96 h / 20 °C

5: 67 percent / DBU / dimethylformamide / 96 h / 20 °C

With pyridine; 1H-imidazole; carbon tetrabromide; ammonia; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.059

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 514211-09-7
1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole; pyridine / 16 h / 20 °C

2: ammonia / methanol / 16 h / 20 °C

3: 8.7 g / acetic acid / 1 h / 20 °C

4: 66 percent / triphenylphosphine; tetrabromomethane / dioxane / 96 h / 20 °C

5: 67 percent / DBU / dimethylformamide / 96 h / 20 °C

With pyridine; 1H-imidazole; carbon tetrabromide; ammonia; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.059