4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

Base Information

Chemical Name:4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine
CAS No.:166758-07-2
Molecular Formula:C₅₃H₅₃N₃O₇Si
Molecular Weight:872.105
Hs Code.:

Synonyms:4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

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Technology Process of 4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

There total 3 articles about 4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67219-55-0
4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

: 58479-61-1
tert-butylchlorodiphenylsilane

: 166758-07-2
4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jo00121a037

Reference yield: 85.0%

: 59921-48-1
N-benzoyltetrazole

: 200702-31-4
2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

: 166758-07-2
4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

Guidance literature:: With dmap; In acetonitrile; at 65 ℃; for 0.25h;
DOI:10.1016/S0040-4039(97)10423-3

Reference yield:

: 98-88-4
benzoyl chloride

: 166758-07-2
4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / triethylamine / tetrahydrofuran / 0.75 h / 0 °C

2: 85 percent / 4-dimethylaminopyridine / acetonitrile / 0.25 h / 65 °C

With dmap; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4039(97)10423-3