2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 866456-21-5
• Molecular Formula: C₁₇H₂₃BrN₂O₃
• Molecular Weight: 383.285

Synonyms:2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (98303-20-9) + 2-bromoaniline (615-36-1) → 2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (866456-21-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1055/s-2005-871563

Reference yield:

C14H23NO6 + 2-bromoaniline (615-36-1) → 2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (866456-21-5)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol101454x

Reference yield: 80.0%

2-(2-bromo-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (866456-21-5) + allyl bromide (106-95-6) → 2-[allyl-(2-bromo-phenyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (866456-24-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1055/s-2005-871563

upstream raw materials:

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid

2-bromoaniline

Downstream raw materials:

2-[allyl-(2-bromo-phenyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

2-[(2-bromo-phenyl)-prop-2-ynyl-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

piperidine-2-carboxylic acid allyl-(2-bromo-phenyl)-amide

4-methylene-1-oxo-2-phenyl-2,6-diaza-spiro[4.5]decane-6-carboxylic acid tert-butyl ester

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