N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
CAS No.:1202757-67-2
Molecular Formula:C₁₉H₁₇FN₆O₃S
Molecular Weight:428.447
Hs Code.:

Synonyms:N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Chemical Property of N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Technology Process of N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

There total 4 articles about N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1202760-29-9
C₁₆H₁₅FN₆O₂S

: 814-68-6,25189-84-8
acryloyl chloride

: 1202757-67-2
N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 1h;

Reference yield:

: 575474-26-9
2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine

: 1202757-67-2
N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol / 16 h / 90 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

With hydrogen; potassium carbonate; palladium 10% on activated carbon; acetic acid; In 1-methyl-pyrrolidin-2-one; methanol; ethanol;

Reference yield:

: 1202760-28-8
C₁₆H₁₃FN₆O₄S

: 1202757-67-2
N-(3-(5-fluoro-2-(3-sulfamoylphenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol;