2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

Base Information

Chemical Name:2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid
CAS No.:1308657-90-0
Molecular Formula:C₂₃H₂₄O₈
Molecular Weight:428.439
Hs Code.:

Synonyms:2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

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Technology Process of 2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

There total 4 articles about 2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1308657-84-2
3-(methoxymethoxy)-5-methyl-2-(1,4,5-trimethoxynaphthalen-2-yl)benzoic acid

: 1308657-90-0
2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

Guidance literature:: With palladium(II) trifluoroacetate; oxygen; cesium acetate; p-benzoquinone; In N,N-dimethyl acetamide; at 140 ℃; for 20h;
DOI:10.1002/hlca.201000296

Reference yield:

: 1308657-82-0
3-(methoxymethoxy)-5-methyl-2-(1,4,5-trimethoxynaphthalen-2-yl)benzaldehyde

: 1308657-90-0
2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; sodium hydroxide / methanol / 1.5 h / 60 - 120 °C

2: palladium(II) trifluoroacetate; oxygen; cesium acetate; p-benzoquinone / N,N-dimethyl acetamide / 20 h / 140 °C

With palladium(II) trifluoroacetate; dihydrogen peroxide; oxygen; cesium acetate; p-benzoquinone; sodium hydroxide; In methanol; N,N-dimethyl acetamide;
DOI:10.1002/hlca.201000296

Reference yield:

: 107941-22-0
2-bromo-1,4,5-trimethoxynaphthalene

: 1308657-90-0
2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1.25 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 48 h / 90 °C

3.1: dihydrogen peroxide; sodium hydroxide / methanol / 1.5 h / 60 - 120 °C

4.1: palladium(II) trifluoroacetate; oxygen; cesium acetate; p-benzoquinone / N,N-dimethyl acetamide / 20 h / 140 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium(II) trifluoroacetate; dihydrogen peroxide; oxygen; cesium acetate; sodium carbonate; p-benzoquinone; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; water; 2.1: Suzuki coupling;
DOI:10.1002/hlca.201000296