1308657-84-2

Upstream product

• 107941-22-0 2-bromo-1,4,5-trimethoxynaphthalene 
• 1308657-82-0 3-(methoxymethoxy)-5-methyl-2-(1,4,5-trimethoxynaphthalen-2-yl)benzaldehyde 

Downstream Products

• 1308657-90-0 2-hydroxy-5-(methoxymethoxy)-3-methyl-6-(1,4,5-trimethoxynaphthalen-2-yl)benzoic Acid 
• 120796-24-9 11-diazonio-10,11-dihydro-4,9-dihydroxy-2-methyl-5,10-dioxo-5H-benzo[b]fluoren-11-ide 

Relevant academic research and scientific papers

Syntheses of prekinamycin and a tetracyclic quinone from common synthetic intermediates

Towards total synthesis of a series of kinamycin and related antibiotics via common synthetic intermediates, total synthesis of prekinamycin was achieved via Suzuki coupling of naphthaleneboronic acid and bromobenzene derivative, intramolecular Friedel-Crafts reaction of 2-(naphthalen-2-yl)benzoic acid, and diazotization in ten steps from 3,5-dimethylphenol. Synthetic studies towards kinamycin antibiotics was also examined, and the tetracyclic quinone core for kinamycins was synthesized. Palladium-catalyzed site-selective hydroxylation of a benzoic acid derivative with the AB-D ring part was successfully applied to the selective D-ring functionalizations. Copyright