(S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline

Base Information

• Chemical Name: (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline
• CAS No.: 121443-92-3
• Molecular Formula: C₂₀H₂₄ClNO₂
• Molecular Weight: 345.869
• Mol file: 121443-92-3.mol

Synonyms:(S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline

Chemical Property of (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline

There total 4 articles about (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-isoquinolinium; GENERIC INORGANIC ANION → (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline (121443-92-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at -78 ℃; for 4h; Yield given;

DOI:10.1021/ja00195a044

Reference yield:

(S)-N-<2-(3,4-Dimethoxyphenyl)ethyl>-1-(2-chlorophenyl)ethylamine (121443-82-1) → (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline (121443-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent

2: phosphorus oxytrichloride / benzene / Heating

3: 1.) Mg / 2.) THF, -78 deg C

With magnesium; trichlorophosphate; In benzene;

DOI:10.1016/S0040-4039(00)94630-6

Reference yield:

methyl bromide (74-83-9) + 2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-3,4-dihydro-isoquinolinium; GENERIC INORGANIC ANION → (S)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline (121443-92-3) + (R)-2-[(S)-1-(2-Chloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline (128598-93-6)

Guidance literature:

With magnesium; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 2.) THF, -78 deg C;

DOI:10.1016/S0040-4039(00)94630-6

upstream raw materials:

methyl bromide

(S)-N-<2-(3,4-Dimethoxyphenyl)ethyl>-1-(2-chlorophenyl)ethylamine

N-[(S)-1-(2-Chloro-phenyl)-ethyl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-formamide