(E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

Base Information

Chemical Name:(E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile
CAS No.:1380092-17-0
Molecular Formula:C₁₈H₂₇NO₄Si
Molecular Weight:349.502
Hs Code.:

Synonyms:(E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

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Chemical Property of (E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

Chemical Property:

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Technology Process of (E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

There total 5 articles about (E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1380092-16-9
2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxybenzaldehyde

: 4336-70-3
(cyanomethyl)triphenylphosphonium chloride

: 1380092-17-0
(E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 25 ℃; for 0.5h;
DOI:10.1016/j.tet.2012.04.024

Reference yield:

: 30225-87-7
2,4,5-trimethoxyphenyl formate

: 1380092-17-0
(E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 2 h

2.1: trifluoroacetic acid / 20 h / Inert atmosphere; Reflux

2.2: 2 h / Reflux

3.1: N,N-dimethyl-formamide / 20 h / 20 °C

4.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C

With trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Duff reaction / 2.2: Duff reaction / 4.1: Wittig reaction;
DOI:10.1016/j.tet.2012.04.024

Reference yield:

: 4460-86-0,14374-62-0
asaraldehyde

: 1380092-17-0
(E)-3-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: potassium hydroxide / ethanol / 2 h

3.1: trifluoroacetic acid / 20 h / Inert atmosphere; Reflux

3.2: 2 h / Reflux

4.1: N,N-dimethyl-formamide / 20 h / 20 °C

5.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Baeyer-Villiger oxidation / 3.1: Duff reaction / 3.2: Duff reaction / 5.1: Wittig reaction;
DOI:10.1016/j.tet.2012.04.024