tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate
CAS No.:1380092-35-2
Molecular Formula:C₂₅H₄₂N₂O₈
Molecular Weight:498.617
Hs Code.:

Synonyms:tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

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Chemical Property of tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

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Technology Process of tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

There total 13 articles about tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₃₃NO₄Si

: 13734-40-2
(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid

: 1380092-35-2
tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: C₁₈H₃₃NO₄Si; (2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2012.04.024

Reference yield:

: C₁₈H₃₃NO₄Si

: 13734-40-2
(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid

: 1380092-35-2
tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

: C₃₁H₅₆N₂O₈Si

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.tet.2012.04.024

Reference yield:

: 1380092-16-9
2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxybenzaldehyde

: 1380092-35-2
tert-butyl (2S,3R)-3-tert-butoxy-1-(3-(2-hydroxy-3,5,6-trimethoxyphenyl)propylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C

2.1: platinum(IV) oxide; hydrogen / ethanol; chloroform / 20 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 1 h / 20 °C

With platinum(IV) oxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 1.1: Wittig reaction;
DOI:10.1016/j.tet.2012.04.024