(9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

Base Information

Chemical Name:(9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate
CAS No.:1340581-05-6
Molecular Formula:C₃₅H₄₀N₂O₄
Molecular Weight:552.714
Hs Code.:

Synonyms:(9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

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Chemical Property of (9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

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Technology Process of (9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

There total 7 articles about (9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1340581-03-4
tert-butyl benzyl(3-(6-(hydroxymethyl)-3,4-dihydro-1H-carbazol-9(2H)-yl)propyl)carbamate

: 98-88-4
benzoyl chloride

: 1340581-05-6
(9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/c2md20211e

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1340581-05-6
(9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; ammonium acetate / diethyl ether / 0.5 h / 20 °C

2.1: 2-methoxy-ethanol / 12 h / 130 °C / Inert atmosphere

3.1: potassium hydroxide / dimethyl sulfoxide / 3 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

5.2: 1 h

6.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7.1: triethylamine / dichloromethane / 12 h / 20 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; 2-methoxy-ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/c2md20211e

Reference yield:

: 21660-16-2
1,2,3,4-tetrahydrocarbazole-6-carboxylic acid ethyl ester

: 1340581-05-6
(9-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 3 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 1 h

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 12 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/c2md20211e