4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

Base Information

Chemical Name:4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester
CAS No.:220878-70-6
Molecular Formula:C₂₇H₃₀Cl₂N₂O₄
Molecular Weight:517.452
Hs Code.:

Synonyms:4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

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Chemical Property of 4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

Chemical Property:

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Technology Process of 4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

There total 3 articles about 4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 152090-65-8
1-(3-Butenyl)cyclopentanecarboxylic acid

: 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester hydrochloride

: 220878-70-6
4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(02)00386-4

Reference yield:

: 4630-80-2
methyl cyclopentane carboxylate

: 220878-70-6
4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / 15 h / -70 - 20 °C

2: 1.0 N NaOH / methanol; tetrahydrofuran / 15 h / Heating

3: HBTU; DIPEA / dimethylformamide / 20 °C

With sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00386-4

Reference yield:

: 220878-56-8
1-but-3-enylcyclopentanecarboxylic acid methyl ester

: 220878-70-6
4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(3-butenyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.0 N NaOH / methanol; tetrahydrofuran / 15 h / Heating

2: HBTU; DIPEA / dimethylformamide / 20 °C

With sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00386-4