2-acetyl-5-methoxyphenyl thiophene-2-carboxylate

Base Information

• Chemical Name: 2-acetyl-5-methoxyphenyl thiophene-2-carboxylate
• CAS No.: 92254-80-3
• Molecular Formula: C₁₄H₁₂O₄S
• Molecular Weight: 276.313
• Mol file: 92254-80-3.mol

Synonyms:2-acetyl-5-methoxyphenyl thiophene-2-carboxylate

Chemical Property of 2-acetyl-5-methoxyphenyl thiophene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-5-methoxyphenyl thiophene-2-carboxylate

There total 1 articles about 2-acetyl-5-methoxyphenyl thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Thiophenecarbonyl chloride (5271-67-0) + 1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) → 2-acetyl-5-methoxyphenyl thiophene-2-carboxylate (92254-80-3)

Guidance literature:

With pyridine; at 25 ℃; for 5h;

DOI:10.1002/ejoc.201100435

Reference yield: 71.0%

2-acetyl-5-methoxyphenyl thiophene-2-carboxylate (92254-80-3) → 1-(2-hydroxy-4-methoxyphenyl)-3-(thiophen-2-yl)propane-1,3-dione (92254-77-8)

Guidance literature:

With potassium carbonate; In pyridine; at 75 ℃;

DOI:10.1002/ejoc.201100435

Reference yield:

2-acetyl-5-methoxyphenyl thiophene-2-carboxylate (92254-80-3) → 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate (1333334-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / pyridine / 75 °C

2: pyridine / 2 h / 25 °C

With pyridine; potassium carbonate; In pyridine; 1: Baker-Venkataraman rearrangement;

DOI:10.1002/ejoc.201100435

upstream raw materials:

2-Thiophenecarbonyl chloride

1-(2-hydroxy-4-methoxyphenyl)ethanone

Downstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)-3-(thiophen-2-yl)propane-1,3-dione

5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate

3-[4-(tert-butoxy)benzyl]-6-methoxy-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one