5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate

Base Information

• Chemical Name: 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate
• CAS No.: 1333334-77-2
• Molecular Formula: C₁₆H₁₄O₅S
• Molecular Weight: 318.35
• Mol file: 1333334-77-2.mol

Synonyms:5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate

Chemical Property of 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate

There total 3 articles about 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(2-hydroxy-4-methoxyphenyl)-3-(thiophen-2-yl)propane-1,3-dione (92254-77-8) + acetic anhydride (108-24-7) → 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate (1333334-77-2)

Guidance literature:

With pyridine; at 25 ℃; for 2h;

DOI:10.1002/ejoc.201100435

Reference yield:

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) → 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate (1333334-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 5 h / 25 °C

2: potassium carbonate / pyridine / 75 °C

3: pyridine / 2 h / 25 °C

With pyridine; potassium carbonate; In pyridine; 2: Baker-Venkataraman rearrangement;

DOI:10.1002/ejoc.201100435

Reference yield:

2-acetyl-5-methoxyphenyl thiophene-2-carboxylate (92254-80-3) → 5-methoxy-2-[3-oxo-3-(thiophen-2-yl)propanoyl]phenyl acetate (1333334-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / pyridine / 75 °C

2: pyridine / 2 h / 25 °C

With pyridine; potassium carbonate; In pyridine; 1: Baker-Venkataraman rearrangement;

DOI:10.1002/ejoc.201100435

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)-3-(thiophen-2-yl)propane-1,3-dione

acetic anhydride

1-(2-hydroxy-4-methoxyphenyl)ethanone

2-acetyl-5-methoxyphenyl thiophene-2-carboxylate