2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

Base Information

Chemical Name:2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester
CAS No.:372523-23-4
Molecular Formula:C₂₃H₂₁NO₆S
Molecular Weight:439.489
Hs Code.:

Synonyms:2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

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Chemical Property of 2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

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Technology Process of 2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

There total 7 articles about 2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 372523-05-2
2-methoxy-5-methylbenzenesulfonic acid 3-[2-(3-allyloxy-4-cyanophenyl)ethoxy]phenyl ester

: 372523-23-4
2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

Guidance literature:: With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm010833f

Reference yield:

: 13398-94-2
2-(3-hydroxyphenyl)ethanol

: 372523-23-4
2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / NaHSO₄*SiO₂ / hexane / 22 h / Heating

2.1: CH₃CH₂MgBr / tetrahydrofuran / 0.5 h

2.2: 96 percent / Et₃N / benzene / 3 h / Heating

3.1: 85 percent / K₂CO₃; MeOH / CHCl₃ / Heating

4.1: 60 percent / NaOAc; nitroethane / Heating

5.1: 77 percent / K₂CO₃; MeOH / 2 h / Heating

6.1: 49 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

7.1: 71 percent / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 3 h / 20 °C

With methanol; sodium tetrahydroborate; sodium hydrogen sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Nitroethane; ethylmagnesium bromide; sodium acetate; silica gel; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; chloroform; 6.1: Mitsunobu reaction;
DOI:10.1021/jm010833f

Reference yield:

: 372522-89-9
acetic acid 2-(4-formyl-3-hydroxyphenyl)ethyl ester

: 372523-23-4
2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / K₂CO₃; MeOH / CHCl₃ / Heating

2: 60 percent / NaOAc; nitroethane / Heating

3: 77 percent / K₂CO₃; MeOH / 2 h / Heating

4: 49 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

5: 71 percent / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 3 h / 20 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Nitroethane; sodium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; chloroform; 4: Mitsunobu reaction;
DOI:10.1021/jm010833f