2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

Base Information

Chemical Name:2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide
CAS No.:736993-87-6
Molecular Formula:C₂₃H₂₈N₄O₄Si
Molecular Weight:452.585
Hs Code.:

2-oxo-4-[(5-trimethylsilanyl-1<i>H</i>-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3a<i>H</i>-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

Synonyms:2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

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Chemical Property of 2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

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Technology Process of 2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

There total 18 articles about 2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 736993-85-4
2-oxo-4-[(2-trimethylsilanyl-ethanesulfonyl)-(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

: 736993-87-6
2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; for 7h; Heating / reflux;

Reference yield: 60.0%

: 736993-85-4
2-oxo-4-[(2-trimethylsilanyl-ethanesulfonyl)-(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

: 2-oxo-4-[(1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

: 736993-87-6
2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 8h; Heating;
DOI:10.1021/ol0490476

Reference yield:

: 250722-66-8
5-TMS-pyrrole-2-carbonyl chloride

: 736993-87-6
2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 10.5 g / Et₃N; 4-dimethylaminopyridine / tetrahydrofuran

2: 60 percent / Bu₃SnH; AIBN / toluene / 8 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/ol0490476