6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Base Information

Chemical Name:6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one
CAS No.:1454580-22-3
Molecular Formula:C₁₈H₁₁F₂NO₄
Molecular Weight:343.286
Hs Code.:

Synonyms:6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Property of 6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

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Technology Process of 6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 3 articles about 6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 81228-09-3
2,4-difluorophenylacetic acid

: 6-(2-bromoacetyl)-2Hbenzo[b][1,4]oxazin-3(4H)-one

: 1454580-22-3
6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: 2,4-difluorophenylacetic acid; 6-(2-bromoacetyl)-2Hbenzo[b][1,4]oxazin-3(4H)-one; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.07.043

Reference yield:

: 26518-71-8
6-acetyl-4H-benzo[1,4]oxazin-3-one

: 1454580-22-3
6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; pyridinium hydrobromide perbromide / acetic acid / 3 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 12 h / 20 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; hydrogen bromide; triethylamine; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.07.043

Reference yield:

: 5466-88-6
3,4-dihydro-3-oxo-2H-1,4-benzoxazine

: 1454580-22-3
6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane

2.1: hydrogen bromide; pyridinium hydrobromide perbromide / acetic acid / 3 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 12 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; pyridinium hydrobromide perbromide; hydrogen bromide; triethylamine; In acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.07.043