26518-71-8

Usage

Uses

Used in Pharmaceutical Industry:
6-Acetyl-2H-1,4-benzoxazin-3(4H)-one is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications, including those targeting cancer, inflammation, and other diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 6-acetyl-2H-1,4-benzoxazin-3(4H)-one is used as a starting material for the development of novel pesticides and herbicides. Its chemical properties make it suitable for the creation of compounds that can effectively control pests and weeds in agricultural settings.
Used in Dye and Pigment Industry:
6-Acetyl-2H-1,4-benzoxazin-3(4H)-one is utilized as a key component in the production of dyes and pigments. Its chemical structure contributes to the development of new colorants with improved properties, such as enhanced color strength, lightfastness, and stability.
Used in Material Science:
In the field of material science, 6-acetyl-2H-1,4-benzoxazin-3(4H)-one is employed as a building block for the synthesis of advanced materials with unique properties. These materials can be used in various applications, such as in the development of new polymers, coatings, and composites with improved mechanical, thermal, and chemical resistance.
Used in Research and Development:
6-Acetyl-2H-1,4-benzoxazin-3(4H)-one is also used as a research compound in academic and industrial laboratories. Its unique structure and reactivity make it an interesting subject for studying various chemical reactions and exploring new synthetic pathways, which can lead to the discovery of novel compounds with potential applications in various industries.

InChI:InChI=1/C10H9NO3/c1-6(12)7-2-3-9-8(4-7)11-10(13)5-14-9/h2-4H,5H2,1H3,(H,11,13)

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 75-36-5 acetyl chloride 
• 27320-78-1 (4-acetyl-2-nitro-phenoxy)-acetic acid ethyl ester 
• 108-24-7 acetic anhydride 
• 6322-56-1 4'-hydroxy-3'-nitroacetophenone 

Downstream Products

• 159459-52-6 6-[1-aminoethyl]-2H-1,4-benzoxazin-3(4H)-one 
• 477312-23-5 (+/-)-1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)ethylamine 
• 697287-41-5 N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide 
• 697287-41-5 (R)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide 
• 6238-95-5 6-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 949398-83-8 6-(3-(3,5-dimethoxyphenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1007743-18-1 6-(3-(2,4-dimethoxyphenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1609463-55-9 6-(3-(4-(benzyloxy)phenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 749924-20-7 6-(3-(4-chlorophenyl)acryloyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1613720-05-0 2-[6-(1-benzhydryl-3-methylazetidin-3-yloxy)-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl]propionic acid ethyl ester 
• 308851-67-4 1-(3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)ethanone 

Relevant academic research and scientific papers

Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth

A series of novel 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives was synthesized. The structures of compounds were characterized by 1H NMR, IR, and MS. Moreover, representative crystal structure was determined by X-ray diffraction ana

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.

Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

Dihydrofuran-2-one and dihydropyrrol-2-one derivatives were identified as novel, potent and selective mineralocorticoid receptor (MR) antagonists by the structure-based drug design approach utilizing the crystal structure of MR/compound complex. Introduct

Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors

An SAR survey at the C-6 benzoxazinone position of a novel scaffold which inhibits bacterial type IIa topoisomerase demonstrates that a range of small electron donating groups (EDG) and electron withdrawing groups (EWG) are tolerated for antibacterial activity. Cyano was identified as a preferred substituent that affords good antibacterial potency while minimizing hERG cardiac channel activity.

POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS

Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds,

COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS

The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.