(S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

Base Information

Chemical Name:(S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone
CAS No.:1374239-01-6
Molecular Formula:C₁₉H₂₁Cl₂N₇O
Molecular Weight:434.328
Hs Code.:

Synonyms:(S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

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Chemical Property of (S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

There total 7 articles about (S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374241-78-7
(S)-N-methyl-N-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 42288-29-9
2-((3,5-dichlorophenyl)arnino)acetic acid

: 1374239-01-6
(S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

Guidance literature:: 2-((3,5-dichlorophenyl)arnino)acetic acid; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃;

(S)-N-methyl-N-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 1374239-01-6
(S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / dichloromethane / Inert atmosphere

1.2: Inert atmosphere; Cooling with ice

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.2: 0 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere; Reflux

5.1: hydrogenchloride; water / ethanol / 5 h / 60 °C

5.2: a polymer supported carbonate resin

6.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0 °C

6.2: 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; water; ammonium formate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1095822-25-5
4-chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1374239-01-6
(S)-1-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)piperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere; Reflux

3.1: hydrogenchloride; water / ethanol / 5 h / 60 °C

3.2: a polymer supported carbonate resin

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0 °C

4.2: 0 - 20 °C

With hydrogenchloride; water; ammonium formate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide;