H-Leu-val-OH

Base Information

• Chemical Name: H-Leu-val-OH
• CAS No.: 13588-95-9
• Molecular Formula: C₁₁H₂₂N₂O₃
• Molecular Weight: 230.307
• DSSTox Substance ID: DTXSID80929169
• Nikkaji Number: J81.649C
• Wikidata: Q27141751
• Metabolomics Workbench ID: 78875
• ChEMBL ID: CHEMBL1222155
• Mol file: 13588-95-9.mol

Synonyms:H-LEU-VAL-OH;13588-95-9;L-Leucyl-L-Valine;Leu-Val;CHEBI:73579;(S)-2-((S)-2-Amino-4-methylpentanamido)-3-methylbutanoic acid;L-Leu-L-Val;L-Leu-L-Val-OH;SCHEMBL3057413;CHEMBL1222155;DTXSID80929169;MDSUKZSLOATHMH-IUCAKERBSA-N;MFCD00038285;AKOS010421665;DS-3264;CS-0145071;A927485;Q27141751;L-V

Chemical Property of H-Leu-val-OH

Chemical Property:

• Vapor Pressure: 2.66E-08mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 421.9°C at 760 mmHg
• PKA: 3.18±0.10(Predicted)
• Flash Point: 209°C
• PSA: 92.42000
• Density: 1.066g/cm³
• LogP: 1.67640
• Storage Temp.: -15°C
• Solubility.: Methanol (Slightly, Sonicated), Water (Sparingly, Sonicated)
• XLogP3: -2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 230.16304257
• Heavy Atom Count: 16
• Complexity: 252

Purity/Quality:

97% ^*data from raw suppliers

Leu-Val-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C(C)C)C(=O)O)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)O)N
• Uses: H-Leu-val-oh can be used to inhibit movement-?induced muscle damage and muscle defective condition.

Technology Process of H-Leu-val-OH

There total 9 articles about H-Leu-val-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-leucyl-L-valine benzyl ester (84111-39-7) → L-leucyl-L-valine (13588-95-9,17665-00-8,35436-83-0,63357-18-6,72121-02-9,76248-09-4,100758-58-5)

Guidance literature:

With hydrogen; palladium; In water; acetic acid; tert-butyl alcohol; Yield given;

DOI:10.1246/bcsj.54.2705

Reference yield:

L-valine benzyl ester p-toluenesulfonate salt (16652-76-9) → L-leucyl-L-valine (13588-95-9,17665-00-8,35436-83-0,63357-18-6,72121-02-9,76248-09-4,100758-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 4 h / 20 °C

2: H₂ / Pd / acetic acid; 2-methyl-propan-2-ol; H₂O

With hydrogen; triethylamine; palladium; In water; acetic acid; acetonitrile; tert-butyl alcohol;

DOI:10.1246/bcsj.54.2705

Reference yield:

L-leucine N-carboxyanhydride (3190-70-3) → L-leucyl-L-valine (13588-95-9,17665-00-8,35436-83-0,63357-18-6,72121-02-9,76248-09-4,100758-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 4 h / 20 °C

2: H₂ / Pd / acetic acid; 2-methyl-propan-2-ol; H₂O

With hydrogen; triethylamine; palladium; In water; acetic acid; acetonitrile; tert-butyl alcohol;

DOI:10.1246/bcsj.54.2705

upstream raw materials:

Z-Leu-Val

N-benzyloxycarbonyl-L-leucine hydrazide

L-valine benzyl ester benzenesulfonate

L-valine

Downstream raw materials:

C₄₉H₇₁N₇O₁₂S